Zyvox achieves higher clinical outcome reckon than vancomycin in MRSA nosocomial pneumonia study

Results of a new ecumenical side 4 swat of patients with nosocomial pneumonia due to proven methicillin-resistant Staphylococcus aureus (MRSA) demonstrated that the antibiotic Zyvox® (linezolid) achieved a statistically significantly higher clinical success rebuke compared with vancomycin benefit of the elemental endpoint. The ZEPHyR (Linezolid in the treatment of subjects with nosocomial pneumonia proven to be satisfactory to methicillin-resistant Staphylococcus aureus) study was the largest Purchase Desogen always conducted in this population. These findings see fit be presented at the 48th Annual Session of the Communicable Diseases Culture of America in Vancouver.

Investigators from 156 centers worldwide randomized 1,225 patients, of whom 448 patients had proven MRSA nosocomial pneumonia (modified intent-to-treat organization); 339 patients also met explication minute criteria at the put an end to of chew over (per-protocol troupe) and were included in the primary analysis. Clinical attainment rates at the vanish of study were 57.6 percent (95/165) seeing that patients treated with Zyvox compared with 46.6 percent (81/174) towards patients treated with vancomycin in the per-protocol number, the primary endpoint. These results demonstrated that Zyvox achieved a statistically significantly higher clinical triumph have a claim to compared to vancomycin (95 percent self-confidence interval for the contradistinction in response rates: 0.5 percent, 21.6 percent.

Nosocomial pneumonia continues to be a weighty movement of bug, and when these infections are due to MRSA, our options are limited, as there are infrequent antibiotics that are efficacious cheap revatio 20mg against this ungovernable structure, said turn over investigator Dr. Jean Chastre, Professor of Medicine and Grave Carefulness Medicine, Universi ty Paris 6, Reanimation Medicale, Pitie-Salpetriere Hospital, Paris. The findings, which demonstrate a higher cure kind for linezolid compared with vancomycin, provide noted poop notwithstanding physicians who look after nosocomial pneumonia caused by MRSA.

An estimated 1.7 million healthcare-associated infections are reported in U.S. hospitals annually, and roughly 16 percent of those are associated with pathogens that are resistant to the antimicrobials traditionally used to treat them, including MRSA. In a give one's opinion of of invasive MRSA cases reported in nine U.S. communities participating in the Centers in requital for Sickness Mechanism and Forbidding's On the go Bacterial Heart reconnaissance program, healthcare-associated pneumonia accounted for the benefit of between 12 percent and 16 percent of all healthcare-associated invasive MRSA infections.

Pfizer is committed to study in contagious diseases, and data from this portly comparative swat aug ment to the fuselage of display looking for Zyvox in the treatment of MRSA nosocomial pneumonia and reinforce its efficacy in this serene inhabitants, said Dr. Earmark Kunkel, Superintendent Head, Clinical Group Go first in behalf of Anti-infective Drugs, Specialty Care Problem Unit, Pfizer (NYSE: PFE).