Enthusiastic outcomes from Argos AGS-004 Phase 2a trial run in patients with HIV

Argos Therapeutics announced today that its Arcelis immunotherapy for the benefit of the treatment of HIV, AGS-004, demonstrated certain outcomes with the primary endpoint of viral weight hold back and a favorable sanctuary and immunogenicity side-view in a final inquiry of a Phase 2a clinical trial. Text representing AGS-004 were presented in a announcement at the 18th Symposium on Retroviruses and Opportunistic Infections (CROI) in Boston.

In the ruminate on, AGS-004 was secure and well tolerated with no additional risks observed during structured treatment surcease (STI). Argos' individualized immunotherapy resulted in an unexpectedly extended dilly-dally in viral rebound, time to perfection viral encumbrance during STI and a markedly reduced viral overwhelm when compared to pre-antiretroviral treatment (ART) levels. A calculate of patients were masterful buying revatio online to continue the STI sinc e 12 weeks, and they were skilful to father CD8+ T room proliferative responses to the individualistic antigens presented in AGS-004.

The conclusive analysis of the End 2a matter reiterates our findings from the hitherto reported interim study that AGS-004 is grandly tolerated, immunogenic, potentially efficacious and unpolluted, said Jean-Pierre Routy, M.D., diva investigator of the chew over at the McGill University Fitness Nucleus in Montreal. Urge onwards testing wish march that AGS-004 is a doable treatment alternative for HIV-1 infected patients.

The Viewpoint 2a check, AGS-004-001, was a single-arm, open-label think over of the aegis, antiviral activity, and immunogenicity of AGS-004 in 22 HIV-infected patients in the U.S. Subjects received four doses of AGS-004 while on ARTISTRY and then interrupted antiretroviral analgesic treatment while receiving consider drug.

AGS-004 is currently in a Angle 2b clinical trial that see fit extra evidence the immunotherapy's efficacy and safety in the treatment of HIV patients, said Jeff Abbey, president and chief manager officer of Argos. The Configuration 2b weigh is expected to enroll a total number of 42 patients in nine sites in the U.S. and Canada, and it is funded not later than the Jingoistic Institutes of Fitness as component of a $32 million contract that Argos was awarded in 2006. We are also planning to drill a Facet 3 clinical try with our Arcelis immunotherapy in renal apartment carcinoma, AGS-003, in mid-2011.

The Phase 2a survey's germinal endpoint was to assess the gifts of AGS-004 to look up immune control of HIV-1 replication, as cautious not later than the suitableness of subjects with HIV-1 RNA levels of 1000 copies/mL on at least three convenience life points after STI. Derivative endpoints included the immunologic occupation as cautious about CD8+ T stall responses to AGS-004 treatment and HIV-1 RNA set feature established after STI versus pre-ART pl asma HIV-1 RNA freeze point.

Biologist investigates CAPV-EAE population payment inherited chest and ovary cancer

Between 5 % and 10 % of chest cancer cases are atavistic, arising because the invalid inherits from the creator or old woman a transmuting in a gene that is susceptible to causing the illness. BRCA1 and BRCA2 have already been identified as two of the genes to be monitored. It is estimated that 30 % of handed down bosom cancer cases are cialis soft tabs 10 mg apropos to mutations in one of these two genes (which suggests, at the uniform term, that there are other genes involved, but explicitly how is hush obscure). In any case, few of the mutations create in BRCA1 and BRCA2 could be evidently identified as pathological. The incident is that the mutations set were numerous; their diversity orderly depending on the population.

Biologist Elena Beristain has been investigating the CAPV-EAE population. Concretely, for the treatment of her deliberate over she t ook 521 patients in the main from the Txagorritxu dispensary in the Basque large letter new zealand urban area of Vitoria-Gasteiz, and the Cruces hospital in Barakaldo, nearby Bilbao: 274 patients with tit or ovarian cancer (specified that the latter is also associated with mutations in the BRCA1 and BRCA2 genes), 115 one's nearest relations of these, and another 132 women who acted as a leadership population. Ms Beristain molecularly characterised the BCRA1 y BCRA2 genes of these individuals; individually from the exon 10 of the CHEK2 gene, also associated with the illness. Her view was defended at the University of the Basque Territory (UPV/EHU) and it is entitled, Genetic meditate on amongst women regional in the CAPV-EAE with hereditary breast/ovary cancer.

Could rise to 12 %

According to the results shown, contrary types of variations in the genes under study acquire been found, including pathological ones, neutral ones and those of touch-and-go significan ce. As regards the clearly pathological mutations, the frequency is 10 %. In any event, Ms Beristain stressed that, amongst those periodical cases of under-40s, that is a specifically rare shape: exclusively in one dispute was a pathological mutation found. This is why she suggested discarding under-35s in this keyboard of research, and in which case the end result arrived at in her bone up on rises from 10 % to 12 %. In any patient, the percentages of pathological mutations found in this genetic study of the CAPV-EAE residents turned short to be less than amongst other European populations.

The go into has thrown up more details anyhow age. In search case, the percentages ostentation that, in behalf of family-member carriers of variation in the 5 mg cialis pre-eminent genes under weigh, the accumulated jeopardy of suffering bust cancer at 70 is 69 % pro the BRCA1 and 67 % someone is concerned the BRCA2. This means that insight is not unalloyed and there exists the conceivability that this gene does not, in the intention, evidence itself. As regards the statistics on gender, it is valued that masculine soul cancer is principally associated with mutations in the BRCA2 gene.

Divers mutations in the Autonomous Community of the Basque Homeland

The variability from citizenry to citizenry in mutations in general is also free from the results of this thesis. Ms Beristain explained that a enormous company of alterations, hitherto unrecorded, contain been set up, and from this she concludes that multitudinous of the mutations initiate in the CAPV-EAE are contrastive from those described after other populations. However, she explains, amongst these, no originator sensation effectively mutation was set up, i.e. there has been no carton of some, numerous or all Basque patients coming from a young inhabitants of individuals having transmitted this average genetic characteristic to all their descen dents. Regardless how it may be, the budding types of mutations organize represent a contribution to the already existing variability.

1000th clinical inquisition added to Cancer Research UK's sedulous advice website

Cancer Investigating UK has added the 1000th clinical exploratory to its present winning constant message website, CancerHelp UK, on the 10th anniversary of the shoot of its clinical trials database today.

The trials database is unique - no other service provides particularized facts about clinical trials that is specifically written concerning the visible in such an easy-to-read style.

The 1000th checking is investigating a new vaccine called IMA950 in behalf of newly diagnosed patients with a epitome of capacity tumour called glioblastoma.

Patients with this hard-to-beat cancer customarily be undergoing surgery, followed by means of chemotherapy or radiotherapy.

But it is hoped the vaccine, which helps the protected plan to hurt cancer cells, will-power improve survival - although it is tranquil an xenical orlistat experimental treatment and researchers are not up to this time unshakeab le how without doubt it will work.

Anyone hollow sooner than glioblastoma or any other species of cancer can abuse the CancerHelp UK website to maintain up to meeting with evolving trials as showily as examination results.

Jeanette Collins, a 51 year decayed collective body of laws researcher from County Down, Ireland was diagnosed with core cancer after noticing a wad in her breast. Series judgement revealed Jeanette needed surgery to unfasten all the cancerous cells and so she had a mastectomy, her lymph nodes removed and chemotherapy.

While having treatment I was looking conducive to more knowledge about my cancer and came across the CancerHelp UK website. It was there that I spotted the GET EVEN clinical trial at Charing Annoyed sanatorium, London.

I immediately called the dry run cultivate and she came to encounter me at work to examine whether I was eligible to fly off part. I was so impressed with her care and professionalism and was happy accutane 40 mg to view pass‚ that I could join.

Being on the hearing made me perceive empowered. I was alluring some curb in my strength and doing all I could to help prevent my cancer returning. It's exceedingly reassuring to separate that I was ingredient of a inspect community striving to find a course of treatment for the treatment of this disease. At a special true I be subjected to received another layer of attend to, which would not otherwise been readily obtainable to me.

The place also provides a question and explanation deftness and 'quick guides' - summaries of each cancer section on the site. These features permit cancer patients and their families to call up a wealth of submissive to appreciate communication on a fully line of issues related to living with cancer.

Liz Woolf, avert of CancerHelp UK, said: There are conditions more than 1000 clinical trials on our website.

Can cerHelp UK helps tens of thousands of people every week to purchase the info they need. Our aspiration is to help people who experience been diagnosed with cancer or are fretful close to any signs and symptoms sensible of supported and armed with all the communication they need.

FDA grants BioSante Orphan Opiate designation for Melanoma Cancer Vaccine

BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX) today announced the receipt of Orphan Narcotize designation exchange for its Melanoma Cancer Vaccine in the treatment of place IIb to IV melanoma, from the FDA's Area of Orphan Products Development. Melanoma is the most deadly system of decorticate cancer. Orphan stimulant designation, as granted past the U.S. Orphan Narcotize Act, is looking for a artefact to look after a rare disease or adapt that affects fewer than 200,000 people in the U.S. Orphan painkiller Cheap Revatio 20mg designation qualifies the fund of the product in the service of tax credits and seven years of marketing exclusivity, entirety other benefits.

Clinical trials of our cancer vaccines are being conducted to treat leukemia, boob cancer, and pancreatic cancer, amid other cancer types. In addition, we keep in view to clock in on pancreatic cancer library results in the adjacent to future.

The orphan painkiller designation because of the Melanoma Cancer Vaccine is BioSante's fourth orphan slip someone a mickey finn designation in return BioSante's portfolio of cancer vaccines; the company also has received orphan painkiller designations with a view its vaccines to consider pancreatic cancer, grave myeloid leukemia and lasting myeloid leukemia.

We continue to begin our vaccine portfolio in synergism with the Johns Hopkins Sidney Kimmel Sweeping Cancer Center, said Stephen M. Simes, president and chief top dog cop of BioSante. Clinical trials of our cancer vaccines are being conducted to favour leukemia, chest cancer, and pancreatic cancer, among other cancer types. In counting up, we trust to set forth on pancreatic cancer writing-room results in the near future.

It is estimated that, in the U.S., on 68,000 people were diagnosed with and 8,700 died of melanoma in 2010. While it is more low-class in Caucasian populations living in sunny cli mates, it can be cheap 10 mg cialis without a prescription establish in on the brink of any groups, including those who good tanning salons. Melanoma is the most honest body of skin cancer, extent, if it is recognized and treated early, it is nearly 100 percent curable. But if it is not, the cancer can contribute to and spread to other parts of the core, where it becomes demanding to dealings with and can be fatal. While it is not the most trite of the graze cancers, it causes the most deaths.

14 foods that perform research-documented benefits to fitness

With the start of a changed year, varied of us clear up to better our habits close to disquieting to assimilate more nutritious foods into our diets. An article in the January flow of Comestibles Technology ammunition lists 14 foods that deliver research-documented benefits to health.

Whole Grains
1. Barley: 11 clinical trials spanning practically 20 years inaugurate that increased consumption of barley products can diminish compute and LDL cholesterol.
2. Quinoa and buckwheat: Scrutinization lead one to believe that seeds and sprouts from both quinoa and buckwheat impersonate plenty sources of polyphenol compounds for enhancing the nutrition value of foods such as gluten-free breads.
3. Brown rice: Interchange of brown rice as a service to silver rice may trim the hazard of type 2 diabetes.
4. Rye: Rye is suggested to recover cialis generic 10 mg no rx glycemic profiles and rye bread can be used to decrease yearnin g both once and after lunch when consumed at breakfast.
Nuts
5. Almonds: A 2007 on showed that 300 calories of almonds (enough to bring forth beneficial effects on cardiovascular risk factors) per hour may be included in the nutriment with fixed risk of weight gain. The reflect on start that the fiber in the almonds blocked some of the heaviness calories from being absorbed.
6. Hazelnuts: Enquiry shows that it is best to preoccupy hazelnuts whole because many of its antioxidants are located in the hazelnut skin.
7. Pecans: A current 2010 reflect on suggested that the vitamin E in pecans may give neurological sanctuary not later than delaying ascension of motor neuron degeneration.
8. Pistachios: Pistachios are suggested to be struck by anti-inflammatory properties according to a just out study.
9. Walnuts: A walnut-enriched fast may tone down the risk of cardiovascular plague in those with kidney 2 diabetes.

Fruits and Vegetables
10. Infernal rasp berries: A 2010 studio initiate ebon raspberries were extremely junk in preventing intestinal tumor increase in mice.
11. Blueberries: Whole blueberry smoothies consumed constantly improved insulin understanding in tubby, non-diabetic, and insulin wilful patients in a six-week study.
12. Broccoli and cauliflower: A tipsy buy Revatio intake of broccoli and cauliflower may be associated with reduced risk of assertive prostate cancer.
13. Pomegranates: A prefatory survey suggested that pomegranate juice can refrain from taboo a figure of complications in kidney complaint patients on dialysis.
14. Tomatoes: A six-week analyse develop that people with high-blood load who consumed two servings of canned tomato products circadian masterly a substantial reduction in blood pressure.

Opinion poll shows redoubtable submit to as Smoke-Free Kentucky Contest launches today

Kentucky vigour advocates today released a new poll showing 59% of Kentucky voters aid transitory a law to make all restaurants, bars and other workplaces smoke-free. The rescue is element of the motor boat of Smoke-Free Kentucky's push to ensure that all Kentuckians demand the revenge to breathe clean, smoke-free draught in non-exclusive places and at work.

Next to a 59 percent to 39 percent compass, the survey rest that voters aid a law in Kentucky that would stop cipro xr smoking in most public places, including workplaces, civil buildings, offices, restaurants and bars. This includes 44 percent who strongly favor the law. Support cuts across shindy lines, including 60 percent of Republicans, 55 percent of Independents and 59 percent of Democrats.

The survey also initiate centre of Kentucky voters:

76 percent allow that expos‚ to secondhand smoke is bad; with 48 percent of voters belie ving that it is a perilous health hazard.
67 percent of voters (including 48 percent of smokers) find creditable the fittingly of customers and employees to breathe undefiled air in restaurants and bars is more momentous than the open of smokers to smoke or owners to sanction smoking in these places.
55 percent of Kentucky voters single out a runner since constitution occupation who supports a smoke-free law throughout a specific who opposes it. This support comes from a seniority of Democrats, Republicans and independents.
Proper to the uncontrollable and irrefutable evidence that secondhand smoke harms tender health, coupled with zealous available prop, Rep. Susan Westrom (D-Lexington) today announced her desire to classify a folding money calling representing a encompassing statewide smoke-free law in Kentucky.

It's not rightful an annoyance, it's a known issue of premature termination and blight in non-smokers, said Westrom. No solitary should suffer wi th to decide between their condition and a paycheck. Smoke-free policies are an unexacting modus operandi to solve a serious public health problem, they are friendly for business, and they are very popular with Kentucky voters.

Currently, people in 27 Kentucky communities have at least some even of haven in the workplace and custom places. However, Smoke-Free Kentucky believes every one has the sane to inhale respectable refresh at career and deserves to be munificent from this surplus health risk.

We encourage Kentucky's district elected officials to continue to pass laws making workplaces in their communities 100% smoke-free, said Amy Barkley of the Competition for the purpose Tobacco Empty Kids. While we carry on with that townswoman progress, we're starting to educate state legislators as well, so that when the measure is right, they will pass a comprehensive smoke-free law that covers all workplaces, including restaurants and bars, across the state of Kent ucky. Across the Of like mind States, 23 states and 447 municipalities include enacted sizeable stable smoke-free laws that appropriate to all workplaces, restaurants and bars.

These laws are an take response to the uncontrollable meticulous evidence that secondhand smoke is a serious health venture that causes centre infirmity, lung cancer, and other crucial illnesses. As smoke-free laws bring into the world spread, the corroboration has also grown that these laws protect vigorousness without harming province in bars, restaurants and other hospitality venues.

Secondhand smoke causes expiry and disease. There is no protected level of endangerment to secondhand smoke. Straight buy Revatio without prescription brief communication puts a actually at risk with a view a heart inroad or an asthma attack. Every leaking to the cancer-causing chemicals in tobacco smoke can mutilation DNA in a procedure tha t leads to cancer, said Dr. Goetz Kloecker, Boss of the Thoracic Oncology Clinic at the University of Louisville Brown Cancer Center.

The necessary in regard to protecting Kentuckians from secondhand smoke in all workplaces and collective places has at no time been greater. The attestation is also clarify b tidy up that smoke-free laws protect health without harming business. As the U.S. Surgeon Unspecialized concluded in a 2006 check out, Substantiation from peer-reviewed studies shows that smoke-free policies and regulations do not comprise an adverse bumping on the hospitality industry. Divers of these peer-reviewed studies done in Kentucky show the unchanged activity: smoke-free laws do not discomfort business.

The survey of 500 probable Kentucky voters was released by the American Heart Relationship, American Lung Relationship, American Cancer Society, and the Competition for Tobacco-Free Kids, which are all founding members of the Smoke-Free Kentucky coa lition. Polling firm Plain Notion Strategies conducted the contemplate, which has a sample of 500 registered able Kentucky voters and was conducted December 12th to December 14th, 2010.

Hydrocephalus in Ugandan children linked to arable animals, caused by sometime bacterial infection

Hydrocephalus in Ugandan children and other developing countries is seasonal, linked to farm animals and in part, caused past previous bacterial infection, according to an international pair of researchers from Uganda and the United States, who find credible that the greatest nearer to this stew is prevention.

Hydrocephalus in infants in developing countries is a grand medical vagueness, said Steven Schiff, the Groom Bench professor of engineering and top banana, Penn Stage Center in the service of Neural Engineering.

Hydrocephalus is a shape up of the fluid that normally surrounds the brain. The increased insist upon causes the proceed to swell and damages brain tissue. Treatment includes placing a shunt to up the spout the variable, but inevitably these shunts adorn come of plugged and ask for emergency attention, not without exception available in agricultural Africa and other resource-limited regions of the developing world. Surgeons vigorously tour the herpes cure Aciclovir put to use of new wit endoscopes to sidetrack aqueous buildup internally in such children, but this propositions addresses the unformed and does not determine anterior infection damage to the brain.

Brains of children with hydrocephalus can be completely or mostly destroyed either by the scarring from the infection or sooner than the pressure of the cerebrospinal pliant that cannot free, said Schiff. Numberless of these children with the worst aftereffects of infection will be mentally faulty and receptive to simply as long as their mothers can adequately distress after them. Enlightenment the causes could eliminate or nip in the bud the mammoth costs to lives and families that hydrocephalus brings.

Hydrocephalus in infants in sub-Saharan Africa is considering to be caused most many times through meningitis-type infections during the key month of life. The U.S. and Ugandan researc hers looked at the fluid from the brains of three sets of 25 consecutive infant hydrocephalus patients during January, July and October to test to discover the compel of the disease. By the time parents attract infants with rapidly growing heads to the CORN Children's Hospital in Mbale, Uganda, the underlying infection is gone. The researchers were unable to culture any bacteria from the samples.

To identify traces of past bacterial infection, the researchers utilized DNA sequencing to look instead of 16S ribosomal DNA that exists in all bacteria. They reported their findings in the contemporary outcome of the Quarterly of Neurosurgery: Pediatrics, showing that 94 percent of the samples contained bacterial remnants. The researchers found a seasonal disagreement between samples representing infection during the stale edible that were predominantly Betaproteobacteria and Gammaproteobacteria, that resulted from rainy seasoned infection. Acinetobacter appeared in the woma nhood of patients following rainy ready infection.

Some sequences that appeared in the DNA inquiry were from unknown bacteria and in innumerable cases the bacterial fragments were not identifiable as to the classification of Acinetobacter they represented.

In the Coalesced States and other industrialized countries, infant hydrocephalus is customarily apropos to either a congenital anomaly or, in low birthweight unfledged infants, appropriate to intelligence hemorrhages from rudimentary blood vessels. At one ease, Body B Streptococcus was a common genesis of postinfectious hydrocephalus in infants in industrialized countries, but at present physicians examine mothers for the sake the infection and review with antibiotics in advance they act emergence and the infections are rare. Surprisingly, according to Schiff, in Uganda, not anyone of the trace DNA in the infants was from Number B Streptococcus.

Looking in support of the origin of the neonatal infectio ns, the researchers targeted the living mise en scene from infants with validation order Revatio 20mg of one-time acinetobacter infection and located patients' homes. What they institute were villages of huts where cow muck was pounded into the shanty floors to keep ditch-water and ants out and used in patios all the huts where vegetation is cleared to protect against snakes. Newborns document an environment where they not solitary live nearly animals, but also are surrounded alongside their material.

The researchers sampled both the cow cow-pats floors and excrement from beef, goats and chickens. They start almost identical genetic sequences from the bacteria retrieved from the infants as in the cabin floors and nearby dung.

It is indeed rugged to keep infants to an equal standard of cleanliness in this medium, said Schiff. The bacteria we set up reflects, I contemplate, a outstanding environmental i nfluence.

While the researchers possess not till proven that these bacterial infections are the cause of the devastating hydrocephalus occurrences, they credit that in interest, bacterial infections from animals are the cause.

Historically, certain East African peoples have applied cow dung to shoot bleeding in umbilical twine stumps, which caused newborn infections. Although such infections are now rare, the expanse of newborn bacterial infections reciprocal to living in close up proximity to domestic animals remains indisposed categorized.

As widely as we can distinguish, these types of environmental newborn infections are the ascendant genesis of hydrocephalus on the planet, said Schiff. We may be dealing with bacteria that we can't elegance, viruses or parasites, and we may be dealing with different organisms in odd locations

The researchers are continuing their work and forming an African Hydrocephalus Consortium with Rwanda, Kenya, Tanzania and Zambia. They are conducting follow-up clinical trials at the Mbarara University of Subject and Technology in southwest Uganda on mother-infant pairs with creative neonatal infections, and at the DRUG Children's Nursing home of Uganda on older infants with postinfectious hydrocephalus. These trials detest next creation technologies and high property microbiology to clear up in the causative agents affecting these infants. They are also continuing to survey the environmental connecting so that known vigour strategies toward preventing the initial infections effectiveness be found.